منابع مشابه
Reducing genomic instability in iPSCs.
Over the past 15 years, pluripotent cells, either embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), became a formidable cellular platform to study developmental biology, model disease in vitro and pursue new drug discoveries. Furthermore, the promise of using endless cell derivatives from pluripotent cells to treat incurable diseases such as diabetes, neurodegenerative or h...
متن کاملTimeline: iPSCs—The First Decade
Research into induced pluripotent stem cells (iPSCs) has expanded at a remarkable pace in the decade since Shinya Yamanaka and Kazutoshi Takahashi first reported their groundbreaking discovery in 2006. This Timeline highlights the key events in the development of this field, including basic insights into the production of iPSCs and how they have been applied to improve our understanding and tre...
متن کاملiPSCs: 10 Years and Counting
Embryos, fetuses, and neonates form perfectly functional tissues and organs every day. Despite fevered efforts over the past 30 years, there has been very modest progress toward achieving the bewitching goal of organ replacement with embryonic or iPSCs. What is the basis of this humbling status quo? Surely one reason is our enduring ignorance of mechanisms governing development in any organ or ...
متن کاملMitochondria fingerprint longevity in iPSCs
The recent and powerful technology of the human induced pluripotent stem cells (iPSCs), (stem cells that are reprogrammed from easily obtainable adult somatic cells such as skin fibroblasts), allows for example to study the pathogenesis of still poorly known human diseases, to perform drug screenings or even to be used in translational medicine [1]. Currently many human diseases suffer from the...
متن کاملClinical Therapy Using iPSCs: Hopes and Challenges
Induced pluripotent stem cells (iPSCs) are generated by ectopic expression of defined transcription factors in somatic cells. They can undergo unlimited self-renewal and maintain the embryonic stem cells (ESCs)-like ability to differentiate into all three germ layers. iPSCs can potentially provide unlimited autologous cells for therapy and therefore hold great promise for regenerative medicine....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2011
ISSN: 1525-0016
DOI: 10.1038/mt.2011.116